Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span
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چکیده
منابع مشابه
Inducible knockdown of pregnancy‐associated plasma protein‐A gene expression in adult female mice extends life span
Pregnancy-associated plasma protein-A (PAPP-A) knockout (KO) mice, generated through homologous recombination in embryonic stem cells, have a significantly increased lifespan compared to wild-type littermates. However, it is unknown whether this longevity advantage would pertain to PAPP-A gene deletion in adult animals. In the present study, we used tamoxifen (Tam)-inducible Cre recombinase-med...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2017
ISSN: 1474-9718
DOI: 10.1111/acel.12624